The basics of gene therapy and its challenges

Research has been conducted on the effects of stem cells on animal models of brain degenerationsuch as in Parkinson'sAmyotrophic lateral sclerosisand Alzheimer's disease.

The basics of gene therapy and its challenges

Methylation is a biochemical process that builds neurotransmitters like dopamine and serotonin, produces energy, processes hormones, builds immune cells, turns genes on and off, synthesizes DNA, produces the protective coating on your nerves and transforms toxins into safer substances.

Chemically speaking, methylation describes the addition of a methyl group to a substrate source material thereby producing a new chemical. Sometimes instead of simply adding a methyl group, some other atom or group in the substrate is replaced. Methylation happens in all the cells of your body distributing methyl CH3 groups to as many as 50 or more other chemical processes in the body.

Methylation depends on a number of vitamins and cofactors which must be present for adequate functioning — those include folate and vitamin B Each of these is a potential weak link which may hobble your methylation cycle because of deficient diet, genetic mutation, toxic exposure, high stress, virus, infection or any combination of those.

Every can of tuna, every plastic bag, Styrofoam cup, cleaning product and consumer product you touch is introducing chemicals into your blood that were unknown years ago. Or maybe you have mercury containing dental fillings. Methylation is catalyzed by enzymes which are fragile and easily damaged by toxins like heavy metals especially mercury.

Here is a more understandable explanation of how Mercury may be related to vitamin B12 written by Christina Bolander-Gouaille: The monovalent cobalt atom in methyl B12 is readily oxidized by various compounds — for instance nitrous oxide.

This oxidation inactivates methioninsyntase MS which has then to be formed de novo. Mercury, as we know, does oxidize many compounds, logically also cobalt. This in turn is one explanation of why symptoms of mercury overload and vitamin Bdeficiency may be identical! There is also a second possible interaction between vitamin B12, and mercury.

High doses of vitamin B12, that overcome the block to some extent, has had sometimes stunning results in these conditions. The good news is this: Your body will begin responding healing within minutes to active B12 supplementation which bypasses the blocks caused by heavy metals, genetic errors polymorphismsstress, etc.

The bad news for some is this: The length of time it takes for you to recover your health will depend on how long it took for you to lose it, and your symptoms may worsen at first during startup.

Still, active B12 therapy has a lot going for it — you can do it on your own without a doctor, the supplements are inexpensive, the risks are low and the results start to show quickly.

If your situation is complicated by heavy metal toxicity, there is a solution for that also called Frequent Dose Chelation which shares some of the same characteristics — also possible without a doctor using inexpensive supplements and carries low risk.

One of the key diagnostics for chronic fatigue is exercise intolerance. What do those of us cursed with exercise intolerance experience?

The basics of gene therapy and its challenges

We pay a terrible penalty for exercising; we become exhausted and may not move for several hours, we get thick brain fog and cognitive impairment, may feel flu-like, may feel anxious or jittery and have difficulty sleeping. The next day, we continue to feel knocked-out and generally function at a low level.

Chronic fatigue is the extreme case that probably helped researchers understand the impact of B12 deficiency and relationship with methylation cycle blocks.

Just as there are many ways for B12 deficiency to express itself, there are multiple causes for B12 deficiency. When a person is sitting on the edge, it can be triggered by any stress that challenges your biology significantly — whether by illness, injury, toxins or even a vaccination.

B12 deficiency can exist in the tissues independent of blood levels and also in the cerebrospinal fluid CSF independent of blood levels and tissue levels. There are two active forms of vitamin B12, of which, you may have a deficiency of either or both. The two active forms of B12 are methylcobalamin also known as methylb12, mb12, mecob, mecbl and adenosylcobalamin also known as adenosylb12, adb12, adob12, cobamamide and dibencozide.

Chemically, methylcobalamin is a co-enzyme for methionine synthase in the methylation cycle whose purpose is to convert homocysteine to methionine.The Most Comprehensive, State-of-the-Art Book on Using Gene and Cell Therapy in Clinical Medicine.

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The basics of gene therapy and its challenges

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Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for .

Jul 11,  · Once just a theory, gene therapies are now a therapeutic reality for some patients. These platforms may have the potential to treat and cure some of our most intractable and vexing diseases.

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use.

Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and.

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